I use LECO PEGASUS^® BT 4D to separate, identify and quantify secondary metabolites of various organisms. The advantages of the GC×GC system in separation of multi-component mixtures allow us to separate and identify a huge number of compounds in every samples. The ability to separate and quantify low levels of target analytes in mixtures simultaneously with the major components presented at a high level of concentration and to separate coeluted compounds is a great advantage of two-dimensional GC in comparison with one-dimensional GC. The user-friendly ChromaTOF software and excellent technical support make LECO a reliable partner for researcher. Since we started working on this equipment, our results have become more accurate and comprehensive, and our research has reached a new level.

In our lab, the GC×GC-MS device installed by LECO has been a game-changer for metabolic profiling, especially in our multiomics study exploring the intricacies of obesity in young adults. Its sensitivity has been crucial in identifying and quantifying metabolites, even at low concentrations, essential for uncovering subtle changes in the metabolome. Our experience with PEGASUS^® BT 4D device has been exceptionally positive, significantly due to the exceptional support of the service team, ensuring the smooth operation and optimal performance of our instrument.

Program

How can we do this?

LECO instrumentation is robust and reliable, allowing us to set up methods in advance that will run in any environment.

Using hydrogen carrier gas vastly speeds up the acquisition process reducing run times by up to 75%.

The instrument will be set up to run your sample allowing our conversation to revolve around your data.

If you want to learn more about our products and solutions for aroma analysis, book a free ticket to our Virtual Trade Show, or schedule an online demo for a deeper insight in our instruments.

WWW.LECO.SHOW

Microplastics are a ubiquitous presence in the world, found from Arctic snow to Antarctic ice and everywhere in between. There are trillions of microplastic particles floating on surface water, and everyone from infants to adults are presumed to be ingesting anywhere from dozens to tens of thousands of these particles every day.

It's that time of year again, when holiday songs play 24/7 on the radio and people start wondering what, exactly, frankincense and myrrh are and why they make good gifts. LECO placed these two oils in a Pegasus BT 4D to see the difference.

Frankincense (from the boswellia tree) and myrrh (from the commiphora tree) are both resins which are commonly used as perfumes and incense and have been for thousands of years. Essential oils extracted from these resins can be analyzed using gas chromatography, which is precisely what the scientists at LECO did.

By extending the analysis to a second dimension using the GC×GC analysis of the Pegasus BT 4D, even more information can be gleaned from the samples extracted from these substances. GC×GC analysis also inherently produces structured chromatograms where chemically similar analytes tend to elute in ordered bands through the GC×GC separation space. This provides context for identification and allows for rapid visual characterization of the compound classes.

For a more detailed breakdown of the analysis of these oils and how the GC×GC separation provides a huge advantage in the characterisation and comparison of these samples, fill in the form and check out our application note.

At our ASMS breakfast seminars, Jean-François (Jef) Focant, Head of the Department of Chemistry and Director of the Organic and Biological Analytical Chemistry group at the University of Liège, Belgium, spoke about using our Pegasus^® BT 4D and Pegasus^® GC-HRT 4D for GC×GC-TOFMS on the breath of asthma patients to improve asthma treatment*. Before diving into the blood and sputum, Jef first educated us on the importance of optimizing your data.

 Non-targeted analysis, data science and innovation have synchronised to underpin the next generation of separation science analysis in mass spectrometry. LECO UK’s separations science product specialist Alan Griffiths explains.

“Ideas often spark one another, and chain reactions occur. As with chemical reactions, ideas can remain contained in relatively small areas before gradually spreading outward. California’s Silicon Valley is a focal point for technology. For mass spectrometry (MS), the UK’s city of Manchester is a focal point. Manchester is where the first commercial mass spectrometer built outside of the US was produced…“

Read the full article here…

Chemistry World // Issue 12/2019 // Article by Alan Griffiths

LECO’s PEGASUS^® GC-HRT⁺ 4D will be the newest addition to the University of Southampton’s School of Chemistry, offering unique capabilities to UK researchers. Read what Professor John Langley has to say about the new mass spectrometer. “Highly advanced Southampton spectrometer to spearhead chemical research across southern region. Researchers across the south of England will analyse novel and strategically important chemistries through a new mass spectrometer at the University of Southampton.“

LECO gave the prize for the best presentation during the 4th International Mass Spectrometry School held in Sitges, Barcelona. We are proud to support young scientists. Congrats Claudia Bressan!